Subhash Sinha, PhD

Subhash Sinha is a synthetic medicinal chemist and Professor of Research in Neuroscience at the Helen and Robert Appel Alzheimer’s Disease Research Institute, Brain and Mind Research Institute, Weill Cornell Medicine. Dr. Sinha received his doctorate in Chemistry-Medicinal Chemistry in 1987 from Banaras Hindu University, India. He completed postdoctoral training at Tohoku University, Japan; Technion-Israel Institute of Technology, Israel; and the Scripps Research Institute, California. 

He joined the Scripps faculty as an Assistant Professor in 1994 and as Associate Professor (of Medicinal Chemistry) in 1999, before moving to the Laboratory of Molecular and Cellular Neurosciences at Rockefeller University (RU) in July 2013 and finally to Weill Cornell Medicine in March 2020. Dr. Sinha has worked across synthetic and medicinal chemistry, including reaction method development and natural product synthesis, enzyme and antibody catalysis, chemical antibody re-programming and drug conjugates, and medicinal and prodrug chemistry. 

At RU in collaboration with the Greengard laboratory, Dr. Sinha identified and developed hit-to-lead compounds for reducing production and oligomerization of A-beta peptides and A-beta levels through mediating autophagy, established a DNA-encoded chemical library synthesis, and provided various chemistry-core support to lab members. At the Appel Institute, Dr. Sinha collaborates closely with other investigators to discover novel small molecule compounds targeting disease modifying pathways for treatment of neurodegenerative diseases.