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2025

DAP12 deletion reduces neuronal SLIT2 and demyelination and enhances brain resilience in female tauopathy mice
Chen H, Fan L, Guo Q, Wong MY, Zhu J, Foxe N, Wang W, Nessim A, Carling G, Liu B, Lopez-Lee C, Huang Y, Amin S, Patel T, Mok SA, Song WM, Zhang B, Gong S, Ma Q, Fu H, Gan L, Luo W (2025). Mol Neurodegener, 20(1):124. doi: 10.1186/s13024-025-00903-3. PMID: 41331787; PMCID: PMC12673724.

High-Throughput Screening and Initial SAR Studies Identify a Novel Submicromolar Potent Human cGAS Inhibitor
Alarcón-Espósito J, Nagiri RK, Wang S, Larson C, Carvallo-Torres L, Singh VK, Glickman JF, Gan L, Sinha SC (2025). ACS Chem Biol. doi: 10.1021/acschembio.5c00649. Epub ahead of print. PMID: 41250566.

Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology
Barnett D, Zimmer TS, Booraem C, Palaguachi F, Meadows SM, Xiao H, Wong MY, Luo W, Gan L, Chouchani ET, Orr AG, Orr AL (2025). Nat Metab, 7(11):2300-2323. doi: 10.1038/s42255-025-01390-y. Epub 2025 Nov 4. PMID: 41188644; PMCID: PMC12616538.

Chaperone-mediated autophagy regulates neuronal excitability by remodeling the synaptic proteome
Khawaja RR, Salek A, Gambardella J, Bourdenx M, Scrivo A, Monday H, Madero J, Lindenau K, Chavda B, Tasset I, Santulli G, Gan L, Castillo P, Cuervo AM (2025). Nat Cell Biol, 27(10):1688-1707. doi: 10.1038/s41556-025-01771-1. Epub 2025 Oct 14. PMID: 41087566.

REV-ERBα regulates brain NAD⁺ levels and neurodegeneration via a brain-specific NFIL3-CD38 axis
Lee J, Kang R, Park S, Saliu IO, Son M, Voorhees JR, Dimitry JM, Quillin EI, Woodie LN, Lananna BV, Gan L, Goo YA, Zhao G, Lazar MA, Burris TP, Musiek ES (2025). Nat Aging, 5(10):2070-2085. doi: 10.1038/s43587-025-00950-x. Epub 2025 Sep 1. PMID: 40890338; PMCID: PMC12532575.

A single-cell long-read isoform resolved case-control study of frontotemporal dementia reveals cell-type specific and broad splicing dysregulation in post-mortem human brain
Belchikov N, Hu W, Fan L, Joglekar A, He Y, Foord C, Jarroux J, Hsu J, Pollard S, Amin S, Prjibelski AD, Gong S, Zhang S, Giannelli R, Seelaar H, Tomescu AI, Ross ME, Li AN, Grinberg LT, Spina S, Miller BL, Cooper-Knock J, Snyder MP, Seeley WW, Rao-Ruiz P, Spijker S, Smit AB, Clelland CD, Gan L, Tilgner HU (2025). Cell Rep, 44(9):116198. doi: 10.1016/j.celrep.2025.116198. Epub 2025 Sep 5. PMID: 40913764; PMCID: PMC12558363.

The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway
Naguib S, Lopez-Lee C, Torres ER, Lee SI, Zhu J, Zhu D, Ye P, Norman K, Zhao M, Wong MY, Ambaw YA, Muñoz-Castañeda R, Wang W, Patel T, Bhagwat M, Norinsky R, Mok SA, Walther TC, Farese RV Jr, Luo W, Sinha SC, Wu Z, Fan L, Gong S, Gan L (2025). Immunity, 58(8):1931-1947.e9. doi: 10.1016/j.immuni.2025.05.023. Epub 2025 Jun 23. PMID: 40555238; PMCID: PMC12406129.

Early life high fructose impairs microglial phagocytosis and neurodevelopment
Wang Z, Lipshutz A, Martínez de la Torre C, Trzeciak AJ, Liu ZL, Miranda IC, Lazarov T, Codo AC, Romero-Pichardo JE, Nair A, Schild T, Saitz Rojas W, Saavedra PHV, Baako AK, Fadojutimi K, Downey MS, Geissmann F, Faraco G, Gan L, Etchegaray JI, Lucas CD, Tanasova M, Parkhurst CN, Zeng MY, Keshari KR, Perry JSA (2025). Nature, 644(8077):759-768. doi: 10.1038/s41586-025-09098-5. Epub 2025 Jun 11. PMID: 40500435; PMCID: PMC7617807.

Combined single-cell profiling of chromatin–transcriptome and splicing across brain cell types, regions and disease state
Hu W, Foord C, Hsu J, Fan L, Corley MJ, Lanjewar SN, Xu S, Belchikov N, He Y, Pang APS, Bhatia TN, Jarroux J, Joglekar A, Milner TA, Ndhlovu LC, Zhang J, Butelman E, Sloan SA, Lee VMY, Gan L, Tilgner HU (2025). Nat Biotechnol, 10.1038/s41587-025-02734-5. doi: 10.1038/s41587-025-02734-5. Epub ahead of print. PMID: 40696189; PMCID: PMC12425497.

Opposing role of phagocytic receptors MERTK and AXL in Progranulin deficient FTD
Clelland CD, Fan L, Saloner R, Etchegaray JI, Altobelli CR, Salomonsson S, Maltos AM, Sachdev A, Zhu J, Lee SI, Li Y, Zhou Y, Le D, Wang C, Carling G, Kodama L, Sayed F, Perez-Bermejo JA, Geier EG, Yokoyama JS, Rosen H, Nana AL, Spina S, Grinberg LT, Seeley WW, Elahi F, Boxer AL, Arkin MR, Gan L (2025). Commun Biol, 8(1):971. doi: 10.1038/s42003-025-08368-2. PMID: 40596721; PMCID: PMC12218935.

Inhibition of soluble epoxide hydrolase confers neuroprotection and restores microglial homeostasis in a tauopathy mouse model
Wang S, Qi C, Rajpurohit C, Ghosh B, Xiong W, Wang B, Qi Y, Hwang SH, Hammock BD, Li H, Gan L, Zheng H (2025). Mol Neurodegener, 20(1):44. doi: 10.1186/s13024-025-00844-x. PMID: 40264187; PMCID: PMC12016400.

Emerging approaches to bridging discovery science with clinical care in Alzheimer's disease
Sinha S, Gan L, Pieper AA (2025). Neurotherapeutics, 22(3):e00589. doi: 10.1016/j.neurot.2025.e00589. PMID: 40246436; PMCID: PMC12047461.

Identification and development of cGAS inhibitors and their uses to treat Alzheimer's disease
Alarcón-Espósito J, Nagiri RK, Gan L, Sinha SC (2025). Neurotherapeutics, 22(3):e00536. doi: 10.1016/j.neurot.2025.e00536. Epub 2025 Jan 31. PMID: 39893084; PMCID: PMC12047402.

2024

Alzheimer’s disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model
Carling GK, Fan L, Foxe NR, Norman K, Wong MY, Zhu D, Corona C, Razzoli A, Yu F, Yarahmady A, Ye P, Chen H, Huang Y, Amin S, Sereda R, Lopez-Lee C, Zacharioudakis E, Chen X, Xu J, Cheng F, Gavathiotis E, Cuervo AM, Holtzman DM, Mok SA, Sinha SC, Sidoli S, Ratan RR, Luo W, Gong S, Gan L (2024). Neuron, 112(23):3877-3896.e8. doi: 10.1016/j.neuron.2024.09.006. Epub 2024 Sep 30. PMID: 39353433; PMCID: PMC11624100.

Tlr7 drives sex differences in age- and Alzheimer's disease-related demyelination
Lopez-Lee C, Kodama L, Fan L, Zhu D, Zhu J, Wong MY, Ye P, Norman K, Foxe NR, Ijaz L, Yu F, Chen H, Carling GK, Torres ER, Kim RD, Dubal DB, Liddelow SA, Sinha SC, Luo W, Gan L (2024). Science, 386(6725):eadk7844. doi: 10.1126/science.adk7844. Epub 2024 Nov 29. PMID: 39607927; PMCID: PMC12396121.

Cellular and pathological functions of tau
Parra Bravo C, Naguib SA, Gan L (2024). Nat Rev Mol Cell Biol, 25(11):845-864. doi: 10.1038/s41580-024-00753-9. Epub 2024 Jul 16. PMID: 39014245.

Anti-acetylated-tau immunotherapy is neuroprotective in tauopathy and brain injury
Parra Bravo C, Krukowski K, Barker S, Wang C, Li Y, Fan L, Vázquez-Rosa E, Shin MK, Wong MY, McCullough LD, Kitagawa RS, Choi HA, Cacace A, Sinha SC, Pieper AA, Rosi S, Chen X, Gan L (2024). Mol Neurodegener, 19(1):51. doi: 10.1186/s13024-024-00733-9. PMID: 38915105; PMCID: PMC11197196.

Human iPSC 4R tauopathy model uncovers modifiers of tau propagation
Parra Bravo C, Giani AM, Madero-Perez J, Zhao Z, Wan Y, Samelson AJ, Wong MY, Evangelisti A, Cordes E, Fan L, Ye P, Zhu D, Pozner T, Mercedes M, Patel T, Yarahmady A, Carling GK, Sterky FH, Lee VMY, Lee EB, DeTure M, Dickson DW, Sharma M, Mok SA, Luo W, Zhao M, Kampmann M, Gong S, Gan L (2024). Cell, 187(10):2446-2464.e22. doi: 10.1016/j.cell.2024.03.015. Epub 2024 Apr 5. PMID: 38582079; PMCID: PMC11365117.

Neuroinflammation generated by HIV-infected microglia promotes dysfunction and death of neurons in human brain organoids
Kong W, Frouard J, Xie G, Corley MJ, Helmy E, Zhang G, Schwarzer R, Montano M, Sohn P, Roan NR, Ndhlovu LC, Gan L, Greene WC (2024). PNAS Nexus, 3(5):pgae179. doi: 10.1093/pnasnexus/pgae179. PMID: 38737767; PMCID: PMC11086946.

Mechanisms of sex differences in Alzheimer's disease
Lopez-Lee C, Torres ERS, Carling G, Gan L (2024). Neuron, 112(8):1208-1221. doi: 10.1016/j.neuron.2024.01.024. Epub 2024 Feb 22. PMID: 38402606; PMCID: PMC11076015.

Novel avenues of tau research
Sexton CE, Bitan G, Bowles KR, Brys M, Buée L, Maina MB, Clelland CD, Cohen AD, Crary JF, Dage JL, Diaz K, Frost B, Gan L, Goate AM, Golbe LI, Hansson O, Karch CM, Kolb HC, La Joie R, Lee SE, Matallana D, Miller BL, Onyike CU, Quiroz YT, Rexach JE, Rohrer JD, Rommel A, Sadri-Vakili G, Schindler SE, Schneider JA, Sperling RA, Teunissen CE, Weninger SC, Worley SL, Zheng H, Carrillo MC (2024). Alzheimers Dement, 20(3):2240-2261. doi: 10.1002/alz.13533. Epub 2024 Jan 3. PMID: 38170841; PMCID: PMC10984447.

Artificial intelligence and open science in discovery of disease-modifying medicines for Alzheimer's disease
Cheng F, Wang F, Tang J, Zhou Y, Fu Z, Zhang P, Haines JL, Leverenz JB, Gan L, Hu J, Rosen-Zvi M, Pieper AA, Cummings J (2024). Cell Rep Med, 5(2):101379. doi: 10.1016/j.xcrm.2023.101379. PMID: 38382465; PMCID: PMC10897520.

KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss
Kauwe G, Pareja-Navarro KA, Yao L, Chen JH, Wong I, Saloner R, Cifuentes H, Nana AL, Shah S, Li Y, Le D, Spina S, Grinberg LT, Seeley WW, Kramer JH, Sacktor TC, Schilling B, Gan L, Casaletto KB, Tracy TE (2024). J Clin Invest, 134(3):e169064. doi: 10.1172/JCI169064. PMID: 38299587; PMCID: PMC10836803.

Cultivation, Differentiation, and Lentiviral Transduction of Human-Induced Pluripotent Stem Cell (hiPSC)-Derived Glutamatergic Neurons for Studying Human Tau
Buchholz S, Bell-Simons M, Cakmak C, Klimek J, Gan L, Zempel H (2024). Methods Mol Biol, 2754:533-549. doi: 10.1007/978-1-0716-3629-9_31. PMID: 38512688.

2023

A global view of aging and Alzheimer's pathogenesis-associated cell population dynamics and molecular signatures in human and mouse brains
Sziraki A, Lu Z, Lee J, Banyai G, Anderson S, Abdulraouf A, Metzner E, Liao A, Banfelder J, Epstein A, Schaefer C, Xu Z, Zhang Z, Gan L, Nelson PT, Zhou W, Cao J (2023). Nat Genet, 55(12):2104-2116. doi: 10.1038/s41588-023-01572-y. Epub 2023 Nov 30. PMID: 38036784; PMCID: PMC10703679.

Mechanism and therapeutic potential of targeting cGAS-STING signaling in neurological disorders
Huang Y, Liu B, Sinha SC, Amin S, Gan L (2023). Mol Neurodegener, 18(1):79. doi: 10.1186/s13024-023-00672-x. PMID: 37941028; PMCID: PMC10634099.

Functional characterization of Alzheimer's disease genetic variants in microglia
Yang X, Wen J, Yang H, Jones IR, Zhu X, Liu W, Li B, Clelland CD, Luo W, Wong MY, Ren X, Cui X, Song M, Liu H, Chen C, Eng N, Ravichandran M, Sun Y, Lee D, Van Buren E, Jiang MZ, Chan CSY, Ye CJ, Perera RM, Gan L, Li Y, Shen Y (2023). Nat Genet, 55(10):1735-1744. doi: 10.1038/s41588-023-01506-8. Epub 2023 Sep 21. PMID: 37735198; PMCID: PMC10939305.

Alzheimer risk-increasing TREM2 variant causes aberrant cortical synapse density and promotes network hyperexcitability in mouse models
Das M, Mao W, Voskobiynyk Y, Necula D, Lew I, Petersen C, Zahn A, Yu GQ, Yu X, Smith N, Sayed FA, Gan L, Paz JT, Mucke L (2023). Neurobiol Dis, 186:106263. doi: 10.1016/j.nbd.2023.106263. Epub 2023 Aug 15. PMID: 37591465; PMCID: PMC10681293.

The AD odyssey 2023: Tales of single cell
Luo W, Qu W, Gan L (2023). Cell, 186(20):4257-4259. doi: 10.1016/j.cell.2023.09.001. PMID: 37774675.

Autophagy prevents microglial senescence
Amin S, Liu B, Gan L (2023). Nat Cell Biol, 25(7):923-925. doi: 10.1038/s41556-023-01168-y. PMID: 37308635.

Tau activation of microglial cGAS–IFN reduces MEF2C-mediated cognitive resilience
Udeochu JC, Amin S, Huang Y, Fan L, Torres ERS, Carling GK, Liu B, McGurran H, Coronas-Samano G, Kauwe G, Mousa GA, Wong MY, Ye P, Nagiri RK, Lo I, Holtzman J, Corona C, Yarahmady A, Gill MT, Raju RM, Mok SA, Gong S, Luo W, Zhao M, Tracy TE, Ratan RR, Tsai LH, Sinha SC, Gan L (2023). Nat Neurosci, 26(5):737-750. doi: 10.1038/s41593-023-01315-6. Epub 2023 Apr 24. PMID: 37095396; PMCID: PMC10166855.

Transposable elements and Alzheimer’s disease pathogenesis
Evering TH, Marston JL, Gan L, Nixon DF (2023). Trends Neurosci, 46(3):170-172. doi: 10.1016/j.tins.2022.12.003. Epub 2022 Dec 30. PMID: 36588011.

Friend turned foe: TREM2 agonist in battles against tau
Carling G, Luo W, Gan L (2023). J Exp Med, 220(1):e20221850. doi: 10.1084/jem.20221850. Epub 2022 Nov 18. PMID: 36399126; PMCID: PMC9680035.

2022

X-linked ubiquitin-specific peptidase 11 increases tauopathy vulnerability in women
Yan Y, Wang X, Chaput D, Shin MK, Koh Y, Gan L, Pieper AA, Woo JA, Kang DE (2022). Cell, 185(21):3913-3930.e19. PMID: 3619831.

A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states
Dräger NM, Sattler SM, Huang C, Teter OM, Leng K, Hashemi SH, Hong J, Aviles G, Clelland CD, Zhan L, Kodama L, Singleton AB, Nalls MA, Ichida J, Ward ME, Faghri F, Gan L, Kampmann M (2022). Nature Neuroscience, 25:1149-1162. PMID: 35953545.

Single-nuclei isoform RNA sequencing unlocks barcoded exon connectivity in frozen brain tissue
Hardwick SA, Hu W, Joglekar A, Fan L, Collier PG, Foord C, Balacco J, Lanjewar S, Sampson MM, Koopmans F, Prjibelski AD, Mikheenko A, Belchikov N, Jarroux J, Lucas AB, Palkovits M, Luo W, Milner TA, Ndhlovu LC, Smit AB, Trojanowski JQ, Lee VMY, Fedrigo O, Sloan SA, Tombácz D, Ross ME, Jarvis E, Boldogkői Z, Gan L, Tilgner HU (2022). Nature Biotechnology, 40:1082-1092. PMID: 35256815.

Familial natural short sleep mutations reduce Alzheimer pathology in mice
Dong Q, Gentry NW, McMahon T, Yamazaki M, Benitez-Rivera L, Wang T, Gan L, Ptáček L, Fu YH (2022). iScience. 25(4):103964. PMID: 35496999.

Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy
Wang C, Fan L, Khawaja RR, Liu B, Zhan L, Kodama L, Chin M, Li Y, Le D, Zhou Y, Condello C, Grinberg LT, Seeley WW, Miller BL, Mok SA, Gestwicki JE, Cuervo AM, Luo W, Gan L (2022). Nature Communications, 13(1):1969. PMID: 35413950. PMCID: PMC9005658.

Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration
Tracy TE, Madero-Pérez J, Swaney DL, Chang TS, Moritz M, Konrad C, Ward ME, Stevenson E, Hüttenhain R, Kauwe G, Mercedes M, Sweetland-Martin L, Chen X, Mok SA, Wong MY, Telpoukhovskaia M, Min SW, Wang C, Sohn PD, Martin J, Zhou Y, Luo W, Trojanowski JQ, Lee VMY, Gong S, Manfredi G, Coppola G, Krogan NJ, Geschwind DH, Gan L (2022). Cell, 185(4):712-728.e14.

Mutant glucocerebrosidase impairs α-synuclein degradation by blockade of chaperone-mediated autophagy
Kuo SH, Tasset I, Cheng MM, Diaz A, Pan MK, Lieberman OJ, Hutten SJ, Alcalay RN, Kim S, Ximénez-Embún P, Fan L, Kim D, Ko HS, Yacoubian T, Kanter E, Liu L, Tang G, Muñoz J, Sardi SP, Li A, Gan L, Cuervo AM, Sulzer D (2022). Science Advances, 8(6):eabm6393. PMID: 35138901.

New insights and therapeutic opportunities for progranulin-deficient frontotemporal dementia
Amin S, Carling G, Gan L (2022). Curr Opin Neurobiol, 72:131-139. doi: 10.1016/j.conb.2021.10.001. Epub 2021 Nov 23. PMID: 34826653.

Sex differences in neurodegeneration: the role of the immune system in humans
Lopez-Lee C, Kodama L, Gan L (2021). Biological Psychiatry, 91(1):72-80. PMID: 33715827.

2021

AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation
Sayed FA, Kodama L, Udeochu JC, Fan L, Carling GK, Le D, Li Q,  Zhou L., Mathys H, Wang M, Niu X, Mazutis L, Jiang X, Wang X, Wong MY, Gao F, Telpoukhovskaia M, Tracy TE, Frost G,  Zhou Y, Li Y, Brendel M,, Qiu Y, Cheng Z, Yu G, Hardy J, Coppola G, Gong S, Wang F, DeTure MA, Zhang B, Xie L, Dickson DW, Luo W, Gan L (2021). Science Translational Medicine, 13(622):eabe3947. PMID: 34851693.

Reducing acetylated tau is neuroprotective in brain injury
Shin MK, Vázquez-Rosa E, Koh Y, Dhar M, Chaubey K, Cintrón-Pérez CJ, Barker S, Miller E, Franke K, Noterman MF, Seth D, Allen RS, Motz CT, Rao SR, Skelton LA, Pardue MT, Fliesler SJ, Wang C, Tracy TE, Gan L, Liebl DJ, Savarraj JPJ, Torres GL, Ahnstedt H, McCullough LD, Kitagawa RS, Choi HA, Zhang P, Hou Y, Chiang CW, Li L, Ortiz F, Kilgore JA, Williams NS, Whitehair VC, Gefen T, Flanagan ME, Stamler JS, Jain MK, Kraus A, Cheng F, Reynolds JD, Pieper AA (2021). Cell, 184(10):2715-2732. PMID: 33852912.

Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice
Caballero B, Bourdenx M, Luengo E, Diaz A, Sohn PD, Chen X, Wang C, Juste YR, Wegmann S, Patel B, Young ZT, Kuo SY, Rodriguez-Navarro JA, Shao H, Lopez MG, Karch CM, Goate AM, Gestwicki JE, Hyman BT, Gan L, Cuervo AM (2021). Nature Communications, 12(1):2238. PMID: 33854069. PMCID: PMC8047017.

2020

A MAC2-positive progenitor-like microglial population is resistant to CSF1R inhibition in adult mouse brain
Zhan L, Fan L, Kodama, L, Sohn PD, Wong MY, Mousa, AG, Zhou Y, Li Y, and Gan L (2020). eLife, 9:e51796. PMID: 33054973; PMCID: PMC7591254.

Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia
Telpoukhovskaia MA, Liu K, Sayed FA, Etchegaray JI, Xie M, Zhan L, Li Y, Zhou Y, Le D, Bahr BA, Bogyo M, Ding S, Gan L (2020). Scientific Reports, 10:13688.

Nanoscopic visualization of restricted nonvolume cholinergic and monoaminergic transmission with genetically encoded sensors
Zhu PK, Zheng WS, Zhang P, Jing M, Borden PM, Ali F, Guo K, Feng J, Marvin JS, Wang Y, Wan J, Gan L, Kwan AC, Lin L, Looger LL, Li Y, Zhang Y (2020). Nano Letters, 20(6):4073-4083. PMID: 32396366.

Microglial microRNAs mediate sex-specific responses to tau pathology
Kodama L, Guzman E, Etchegaray JI, Li Y, Sayed FA, Zhou L, Zhou Y, Zhan L, Le D, Udeochu JC, Clelland CD, Cheng Z, Yu G, Li Q, Kosik KS, Gan L (2020). Nature Neuroscience, 23(2):167-171. PMID: 31873194.

Astrocyte senescence promotes glutamate toxicity in cortical neurons
Limbad C, Oron TR, Alimirah F, Davalos AR, Tracy TE, Gan L, Desprez PY, Campisi J (2020) PLoS ONE, 15(1):e0227887. PMID: 31945125.

Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy
Chen X, Li Y, Wang C, Tang Y, Mok SA, Tsai RM, Rojas JC, Karydas A, Miller BL, Boxer AL, Gestwicki JE, Arkin M, Cuervo AM, Gan L (2020). Mol Neurodegener, 15(1):2. doi: 10.1186/s13024-019-0354-0. PMID: 31906970; PMCID: PMC6945522.

2019

A comprehensive resource for induced pluripotent stem cells from patients with primary tauopathies
Karch CM, Kao AW, Karydas A, Onanuga K, Martinez R, Argouarch A, Wang C, Huang C, Sohn PD, Bowles KR, Spina S, Silva MC, Marsh JA, Hsu S, Pugh DA, Ghoshal N, Norton J, Huang Y, Lee SE, Seeley WW, Theofilas P, Grinberg LT, Moreno F, McIlroy K, Boeve BF, Cairns NJ, Crary JF, Haggarty SJ, Ichida JK, Kosik KS, Miller BL, Gan L, Goate AM, Temple S; Tau Consortium Stem Cell Group (2019). Stem Cell Reports,13(5):939-955. PMID: 31631020.

Pathogenic tau impairs axon initial segment plasticity and excitability homeostasis
Sohn PD, Huang C, Tracy TE, Yan R, Camargo CM, Mok SA, Freilich R, Baik J, He M, Roberson ED, Karch CM, Gestwicki JE, Xu K, Kosik KS, and Gan L (2019). Neuron, 104(3):458-470.e5. PMID: 31542321.

Preferential tau aggregation in von Economo neurons and fork cells in frontotemporal lobar degeneration with specific MAPT variants
Lin LC, Nana AL, Hepker M, Hwang JL, Gaus SE, Spina S, Cosme CG, Gan L, Grinberg LT, Geschwind DH, Coppola G, Rosen HJ, Miller BL, Seeley WW (2019). Acta Neuropathologica Communications, 7(1):159. PMID: 31640778.

Do microglial sex differences contribute to sex differences in neurodegenerative diseases?
Kodama L, Gan L (2019). Trends in Molecular Medicine, 25(9):741-749.

Mapping cis-regulatory chromatin contacts in neural cells links neuropsychiatric disorder risk variants to target genes
Song M, Yang X, Ren X, Maliskova L, Li B, Jones IR, Wang C, Jacob F, Wu K, Traglia M, Tam TW, Jamieson K, Lu SY, Ming GL, Li Y, Yao J, Weiss LA, Dixon JR, Judge LM, Conklin BR, Song H, Gan L, Shen Y (2019). Nat Genet, 51(8):1252-1262. doi: 10.1038/s41588-019-0472-1. Epub 2019 Jul 31. PMID: 31367015; PMCID: PMC6677164.

Proximal recolonization by self-renewing microglia re-establishes microglial homeostasis in the adult mouse brain
Zhan L, Krabbe G, Du F, Jones I, Reichert MC, Telpoukhovskaia M, Kodama L, Wang C, Cho S, Sayed FA, Li Y, Le D, Zhou Y, Shen Y, West B, and Gan L (2019). PLoS Biology, 17(2):e3000134. PMID: 30735499.

Regulation of Tau Homeostasis and Toxicity by Acetylation
Tracy T, Claiborn KC, Gan L (2019). Adv Exp Med Biol, 1184:47-55. doi: 10.1007/978-981-32-9358-8_4. PMID: 32096027.

An exercise-induced messenger boosts memory in Alzheimer's disease
Chen X, Gan L (2019). Nat Med, 25(1):20-21. doi: 10.1038/s41591-018-0311-4. PMID: 30617321.

2018

Military-related risk factors for dementia
Snyder HM, Carare RO, DeKosky ST, de Leon MJ, Dykxhoorn D, Gan L, Gardner R, Hinds SR 2nd, Jaffee M, Lamb BT, Landau S, Manley G, McKee A, Perl D, Schneider JA, Weiner M, Wellington C, Yaffe K, Bain L, Pacifico AM, Carrillo MC (2018). Alzheimers Dement, 14(12):1651-1662. doi: 10.1016/j.jalz.2018.08.011. Epub 2018 Nov 8. PMID: 30415806; PMCID: PMC6281800.

Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy
Sayed FA, Telpoukhovskaia M, Kodama L, Li Y, Zhou Y, Le D, Hauduc A, Ludwig C, Gao F, Clelland C, Zhan L, Cooper YA, Davalos D, Akassoglou K, Coppola G, Gan L (2018). Proceedings of the National Academy of Sciences of the United States of America, 115(40):10172-10177. PMID: 30232263.

Converging pathways in neurodegeneration, from genetics to mechanisms
Gan L, Cookson MR, Petrucelli L, La Spada AR (2018). Nature Neuroscience, 21(10):1300-1309. PMID: 30258237.

Tau-mediated synaptic and neuronal dysfunction in neurodegenerative disease
Tracy TE, Gan, L (2018). Current Opinion in Neurobiology, 51:134-138. PMID: 29753269. PMCID: PMC6130905.

The Psychiatric Cell Map Initiative: A convergent systems biological approach to illuminating key molecular pathways in neuropsychiatric disorders
Willsey AJ, Morris MT, Wang S, Willsey HR, Sun N, Teerikorpi N, Baum TB, Cagney G, Bender KJ, Desai TA, Srivastava D, Davis GW, Doudna J, Chang E, Sohal V, Lowenstein DH, Li H, Agard D, Keiser MJ, Shoichet B, von Zastrow M, Mucke L, Finkbeiner S, Gan L, Sestan N, Ward ME, Huttenhain R, Nowakowski TJ, Bellen HJ, Frank LM, Khokha MK, Lifton RP, Kampmann M, Ideker T, State MW, Krogan NJ (2018). Cell, 174(3):505-520. PMID: 300534.

Transcription factor-mediated differentiation of human iPSCs into neurons
Fernandopulle MS, Prestil R, Grunseich C, Wang C, Gan L, Ward ME (2018). Current Protocols in Cell Biology, 79(1):e51. PMID: 29924488.

SIRT1 deacetylates tau and reduces pathogenic tau spread in a mouse model of tauopathy
Min SW, Sohn PD, Li Y, Devidze N, Johnson JR, Krogan NJ, Masliah E, Mok SA, Gestwicki JE, Gan L (2018). The Journal of Neuroscience, 38(15):3680-3688. 

Nav1.1-overexpressing interneuron transplants restore brain rhythms and cognition in a mouse model of Alzheimer’s disease
Martinez-Losa M, Tracy TE, Ma K, Verret L, Clemente-Perez A, Khan AS, Cobos I, Ho K, Gan L, Mucke L, Alvarez-Dolado M, Palop JJ (2018). Neuron, 98(1):75-89. PMID:29551491.

TREM2 and amyloid beta: a love-hate relationship
Udeochu J, Sayed FA, Gan L (2018) Neuron, 97(5):991-993.

Endo-lysosomal dysfunction: a converging mechanism in neurodegenerative diseases
Wang C, Telpoukhovskaia MA, Bahr BA, Chen X, Gan L (2018). Curr Opin Neurobiol, 48:52-58. doi: 10.1016/j.conb.2017.09.005. Epub 2017 Oct 10. PMID: 29028540.

2017

Systematic three-dimensional coculture rapidly recapitulates interactions between human neurons and astrocytes
Krencik R, Seo K, van Asperen JV, Basu N, Cvetkovic C, Barlas S, Chen R, Ludwig C, Wang C, Ward ME, Gan L, Horner PJ, Rowitch DH, Ullian EM (2017). Stem Cell Reports, 9(6):1745-1753. PMID:29198827.

An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons
Boselli M, Lee BH, Robert J, Prado MA, Min SW, Cheng C, Silva MC, Seong C, Elsasser S, Hatle KM, Gahman TC, Gygi SP, Haggarty SJ, Gan L, King RW, Finley D (2017). The Journal of Biological Chemistry, 292(47):19209-19225. PMID: 28972160.

An 8-week, open-label, dose-finding study of nimodipine for the treatment of progranulin insufficiency from GRN gene mutations
Sha SJ, Miller ZA, Min SW, Zhou Y, Brown J, Mitic LL, Karydas A, Koestler M, Tsai R, Corbetta-Rastelli C, Lin S, Hare E, Fields S, Fleischmann KE, Powers R, Fitch R, Martens LH, Shamloo M, Fagan AM, Farese RV Jr, Pearlman R, Seeley W, Miller BL, Gan L, Boxer AL (2017). Alzheimer's & Dementia (New York, N. Y.), 3(4):507-512. PMID:2912410.

Scalable production of iPSC-derived human neurons to identify tau-lowering compounds by high-content screening
Wang C, Ward ME, Chen R, Liu K, Tracy TE, Chen X, Xie M, Sohn PD, Ludwig C, Meyer-Franke A, Karch CM, Ding S, Gan L (2017). Stem Cell Reports, 9(4):1221-1233. PMID: 28966121. PMCID: PMC5639430.

Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia
Krabbe G, Minami SS, Etchegaray JI, Taneja P, Djukic B, Davalos D, Le D, Lo I, Zhan L, Reichert MC, Sayed F, Merlini M, Ward ME, Perry DC, Lee SE, Sias A, Parkhurst CN, Gan WB, Akassoglou K, Miller BL, Farese RV Jr, Gan L (2017). Proceedings of the National Academy of Sciences of the United States of America, 114(19):5029-5034. PMID: 28438992.

Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis
Ward ME, Chen R, Huang HY, Ludwig C, Telpoukhovskaia M, Taubes A, Boudin H, Minami SS, Reichert M, Albrecht P, Gelfand JM, Cruz-Herranz A, Cordano C, Alavi MV, Leslie S, Seeley WW, Miller BL, Bigio E, Mesulam MM, Bogyo MS, Mackenzie IR, Staropoli JF, Cotman SL, Huang EJ, Gan L, Green AJ (2017). Science Translational Medicine, 9:eaah5642. PMID: 28404863.

Acetylated tau in Alzheimer's disease: An instigator of synaptic dysfunction underlying memory loss: Increased levels of acetylated tau blocks the postsynaptic signaling required for plasticity and promotes memory deficits associated with tauopathy
Tracy TE, Gan L (2017). Bioessays, 39(4):10.1002/bies.201600224. doi: 10.1002/bies.201600224. Epub 2017 Jan 13. PMID: 28083916; PMCID: PMC5903676.

2016

Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor
Möller T, Bard F, Bhattacharya A, Biber K, Campbell B, Dale E, Eder C, Gan L, Garden GA, Hughes ZA, Pearse DD, Staal RG, Sayed FA, Wes PD, Boddeke HW (2016). Glia, 64(10):1788-94. PMID: 27246804.

Targeting microglia for the treatment of Alzheimer’s Disease
Wes PD, Sayed FA, Bard F, Gan L (2016). Glia, 64(10):1710-32. PMID: 27100611.

Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment
Sohn PD, Tracy TE, Son HI, Zhou Y, Leite RE, Miller BL, Seeley WW, Grinberg LT, Gan L (2016). Molecular Neurodegeneration, 11(1):47. PMID: 27356871. PMCID: PMC4928318.

Acetylated tau obstructs KIBRA-mediated signaling in synaptic plasticity and promotes tauopathy-related memory loss
Tracy TE, Sohn PD, Minami SS, Wang C, Min SW, Li Y, Zhou Y, Le D, Lo I, Ponnusamy R, Cong X, Schilling B, Ellerby LM, Huganir RL, Gan L (2016). Neuron, 90(2):245-60. PMID: 27041503. PMCID: PMC4859346.

2015

Reducing inflammation and rescuing FTD-related behavioral deficits in progranulin-deficient mice with α7 nicotinic acetylcholine receptor agonists
Minami SS, Shen V, Le D, Krabbe G, Asgarov R, Perez-Celajes L, Lee CH, Li J, Donnelly-Roberts D, Gan L (2015). Biochemical Pharmacology, 97(4):454-462. PMID: 26206194. PMCID: PMC4859338.

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits
Min SW, Chen X, Tracy TE, Li Y, Zhou Y, Wang C, Shirakawa K, Minami SS, Defensor E, Mok SA, Sohn PD, Schilling B, Cong X, Ellerby L, Gibson BW, Johnson J, Krogan N, Shamloo M, Gestwicki J, Masliah E, Verdin E, Gan L (2015). Nature Medicine, 21(10):1154-62. PMID: 26390242. PMCID: PMC4598295.

SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1β
Cho SH, Chen JA, Sayed F, Ward ME, Gao F, Nguyen TA, Krabbe G, Sohn PD, Lo I, Minami S, Devidze N, Zhou Y, Coppola G, Gan L (2015). The Journal of Neuroscience, 35(2):807-18. PMID: 25589773. PMCID: PMC4293425.

2014

Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models
Minami SS, Min SW, Krabbe G, Wang C, Zhou Y, Asgarov R, Li Y, Martens LH, Elia LP, Ward ME, Mucke L, Farese RV, Gan L (2014). Nature Medicine, 20(10):1157-64. PMID: 25261995. PMCID: PMC4196723.

Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD
Ward ME, Taubes A, Chen R, Miller BL, Sephton CF, Gelfand JM, Minami S, Boscardin J, Martens LH, Seeley WW, Yu G, Herz J, Filiano AJ, Arrant AE, Roberson ED, Kraft TW, Farese RV, Green A, Gan L (2014). The Journal of Experimental Medicine, 211(10):1937-45. PMID: 25155018. PMCID: PMC4172214.
* Nature Research Highlight: ”Eyes offer window on dementia”

2013

Sirtuins in neurodegenerative diseases: an update on potential mechanisms
Min SW, Sohn PD, Cho SH, Swanson RA, Gan L (2013). Frontiers in Aging Neuroscience, 5:53. PMID: 24093018. PMCID: PMC3782645.

Poly(ADP-ribose) polymerase-1-induced NAD(+) depletion promotes nuclear factor-κB transcriptional activity by preventing p65 de-acetylation
Kauppinen TM, Gan L, Swanson RA (2013). Biochimica et Biophysica Acta, 1833(8):1985-91. PMID: 23597856. PMCID: PMC4041949.

Argyrophilic grain disease differs from other tauopathies by lacking tau acetylation
Grinberg LT, Wang X, Wang C, Sohn PD, Theofilas P, Sidhu M, Arevalo JB, Heinsen H, Huang EJ, Rosen H, Miller BL, Gan L, Seeley WW (2013). Acta Neuropathologica, 125(4):581-93. PMID: 23371364. PMCID: PMC3692283.

2012

Transcriptional expression patterns triggered by chemically distinct neuroprotective molecules
Pappas DJ, Gabatto PA, Oksenberg D, Khankhanian P, Baranzini SE, Gan L, Oksenberg JR (2012). Neuroscience, 226:10-20. PMID: 22986168. PMCID: PMC3489981.

Cathepsin B degrades amyloid-β in mice expressing wild-type human amyloid precursor protein
Wang C, Sun B, Zhou Y, Grubb A, Gan L (2012). The Journal of Biological Chemistry, 287(47):39834-41. PMID: 23024364. PMCID: PMC3501032.

Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury
Martens LH, Zhang J, Barmada SJ, Zhou P, Kamiya S, Sun B, Min SW, Gan L, Finkbeiner S, Huang EJ, Farese RV (2012). The Journal of Clinical Investigation, 122(11):3955-9. PMID: 23041626. PMCID: PMC3484443.

Selective targeting of microglia by quantum dots
Minami SS, Sun B, Popat K, Kauppinen T, Pleiss M, Zhou Y, Ward ME, Floreancig P, Mucke L, Desai T, Gan L (2012). Journal of Neuroinflammation, 9:22. PMID: 22272874. PMCID: PMC3292839.

2011

Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid β
Kauppinen TM, Suh SW, Higashi Y, Berman AE, Escartin C, Won SJ, Wang C, Cho SH, Gan L, Swanson RA (2011). Journal of Neuroinflammation, 8:152. PMID: 22051244. PMCID: PMC3247192.

Protective effects and mechanisms of sirtuins in the nervous system
Zhang F, Wang S, Gan L, Vosler PS, Gao Y, Zigmond MJ, Chen J (2011). Progress in Neurobiology, 95(3):373-95. PMID: 21930182. PMCID: PMC3242010.

CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease
Cho SH, Sun B, Zhou Y, Kauppinen TM, Halabisky B, Wes P, Ransohoff RM, Gan L (2011). The Journal of Biological Chemistry, 286(37):32713-22. PMID: 21771791. PMCID: PMC3173153.

Manipulation of gene expression in the central nervous system with lentiviral vectors
Sun B, Gan L (2011). Methods Mol Biol, 670:155-68. doi: 10.1007/978-1-60761-744-0_12. PMID: 20967590.

2010

Acetylation of tau inhibits its degradation and contributes to tauopathy
Min SW, Cho SH, Zhou Y, Schroeder S, Haroutunian V, Seeley WW, Huang EJ, Shen Y, Masliah E, Mukherjee C, Meyers D, Cole PA, Ott M, Gan L (2010). Neuron, 67(6):953-66. PMID: 20869593. PMCID: PMC3035103.
* Previewed in Neuron

2009

Imbalance between GABAergic and Glutamatergic transmission impairs adult neurogenesis in an animal model of Alzheimer's Disease
Sun B, Halabisky B, Zhou Y, Palop JJ, Yu G, Mucke L, Gan L (2009). Cell Stem Cell, 5(6):624-33. PMID: 19951690. PMCID: PMC2823799.

2008

Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease
Sanchez-Mejia RO, Newman JW, Toh S, Yu GQ, Zhou Y, Halabisky B, Cissé M, Scearce-Levie K, Cheng IH, Gan L, Palop JJ, Bonventre JV, Mucke L. (2008). Nature Neuroscience, 11(11):1311-8. PMID: 18931664. PMCID: PMC2597064.

Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer’s disease
Sun B, Zhou Y, Halabisky B, Lo I, Cho SH, Mueller-Steiner S, Devidze N, Wang X, Grubb A, Gan L (2008). Neuron, 60(2):247-57. PMID: 18957217. PMCID: PMC2755563.

Paths of convergence: Sirtuins in aging and neurodegeneration
Gan L, Mucke L. (2008). Neuron, 58(1):10-4. PMID: 18400158.

2007

Therapeutic potential of sirtuin-activating compounds in Alzheimer’s disease
Gan L (2007). Drug News & Perspectives, 20(4):233-9. PMID: 17637936.

2006

Antiamyloidogenic and neuroprotective functions of cathepsin B: Implications for Alzheimer’s disease
Mueller-Steiner S, Zhou Y, Arai H, Roberson ED, Sun B, Chen J, Wang X, Yu G, Esposito L, Mucke L, Gan L (2006). Neuron, 51(6):703-14. PMID: 16982417. 
* Previewed in Neuron and commented in Lancet Neurology

2005

SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling
Chen J, Zhou Y, Mueller-Steiner S, Chen LF, Kwon H, Yi S, Mucke L, Gan L (2005). The Journal of Biological Chemistry, 280(48):40364-74. PMID: 16183991.

Regulation of the timing of MNTB neurons by short-term and long-term modulation of potassium channels
Kaczmarek LK, Bhattacharjee A, Desai R, Gan L, Song P, von Hehn CA, Whim MD, Yang B. (2005). Hearing Research, 206(1-2):133-45. PMID: 16081004.

2004

Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells
Esposito L, Gan L, Yu GQ, Essrich C, Mucke L (2004). Journal of Neurochemistry, 91(6):1260-74. PMID: 15584903.

New non-viral method for gene transfer into primary cells
Gresch O, Engel FB, Nesic D, Tran TT, England HM, Hickman ES, Körner I, Gan L, Chen S, Castro-Obregon S, Hammermann R, Wolf J, Müller-Hartmann H, Nix M, Siebenkotten G, Kraus G, Lun K (2004). Methods, 33(2):151-63. PMID: 15121170.

Identification of cathepsin B as a mediator of neuronal death induced by Abeta-activated microglial cells using a functional genomics approach
Gan L, Ye S, Chu A, Anton K, Yi S, Vincent VA, von Schack D, Chin D, Murray J, Lohr S, Patthy L, Gonzalez-Zulueta M, Nikolich K, Urfer R (2004). The Journal of Biological Chemistry, 279(7):5565-72. PMID: 14612454.

2003

Neuregulin-1 suppresses muscarinic receptor expression and acetylcholine-activated muscarinic K+ channels in cardiac myocytes
Ford BD, Liu Y, Mann MA, Krauss R, Phillips K, Gan L, Fischbach GD (2003). Biochemical and Biophysical Research Communications, 308(1):23-8. PMID: 12890474.

2002

Localization of the Slack potassium channel in the rat central nervous system
Bhattacharjee A, Gan L, Kaczmarek LK (2002). The Journal of Comparative Neurology, 454(3):241-54. PMID: 12442315.

Specific interference with gene expression and gene function mediated by long dsRNA in neural cells
Gan L, Anton KE, Masterson BA, Vincent VA, Ye S, Gonzalez-Zulueta M (2002). Journal of Neuroscience Methods, 121(2):151-7. PMID: 12468005.

Pre-2000

Cell type-specific expression of the Kv3.1 gene is mediated by a negative element in the 5’ untranslated region of the Kv3.1 promoter
Gan L, Hahn SJ, Kaczmarek LK (1999). Journal of Neurochemistry, 73(4):1350-62. PMID: 10501178.

Wild-type but not Alzheimer-mutant amyloid precursor protein confers resistance against p53-mediated apoptosis
Xu X, Yang D, Wyss-Coray T, Yan J, Gan L, Sun Y, Mucke L (1999). Proceedings of the National Academy of Sciences of the United States of America, 96(13):7547-52. PMID: 10377452. PMCID: PMC22123.

Formation of intermediate-conductance calcium-activated potassium channels by interaction of Slack and Slo subunits
Joiner WJ, Tang MD, Wang LY, Dworetzky SI, Boissard CG, Gan L, Gribkoff VK, Kaczmarek LK (1998). Nature Neuroscience, 1(6):462-9. PMID: 10196543.

When, where, and how much? Expression of the Kv3.1 potassium channel in high-frequency firing neurons
Gan L, Kaczmarek LK (1998). Journal of Neurobiology, 37(1):69-79. PMID: 9777733.

Contribution of the Kv3.1 potassium channel to high-frequency firing in mouse auditory neurones
Wang LY, Gan L, Forsythe ID, Kaczmarek LK (1998). The Journal of Physiology, 509 (Pt 1):183-94. PMID: 9547392. PMCID: PMC2230948.

Activation of Kv3.1 channels in neuronal spine-like structures may induce local potassium ion depletion
Wang LY, Gan L, Perney TM, Schwartz I, Kaczmarek LK (1998). Proceedings of the National Academy of Sciences of the United States of America, 95(4):1882-7. PMID: 9465111. PMCID: PMC19207.

Cloning and characterization of the promoter for a potassium channel expressed in high frequency firing neurons
Gan L, Perney TM, Kaczmarek LK (1996). The Journal of Biological Chemistry, 271(10):5859-65. PMID: 8621457.

Electrophysiological and pharmacological characterization of a mammalian Shaw channel expressed in NIH 3T3 fibroblasts
Kanemasa T, Gan L, Perney TM, Wang LY, Kaczmarek LK (1995). Journal of Neurophysiology, 74(1):207-17. PMID: 7472324.