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Gan Laboratory
Research
Team
Current Members
Alumni
Publications
News
Life in the Lab
Core Values
Research
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Alzheimer’s disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model (Copy)
NIAN Claire Hu 4/25/24 NIAN Claire Hu 4/25/24

Alzheimer’s disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model (Copy)

Neuron, 2024

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HSCDM ScienceSites 9/20/23 HSCDM ScienceSites 9/20/23

A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states

Nature Neuroscience, 2022

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HSCDM ScienceSites 9/20/23 HSCDM ScienceSites 9/20/23

Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration

Cell, 2022

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HSCDM ScienceSites 9/20/23 HSCDM ScienceSites 9/20/23

Pathogenic tau impairs axon initial segment plasticity and excitability homeostasis

Neuron, 2019

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HSCDM ScienceSites 9/20/23 HSCDM ScienceSites 9/20/23

Scalable production of iPSC-derived human neurons to identify tau-lowering compounds by high-content screening

Stem Cell Reports, 2017

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HSCDM ScienceSites 9/20/23 HSCDM ScienceSites 9/20/23

Imbalance between GABAergic and glutamatergic transmission impairs adult neurogenesis in an animal model of Alzheimer's Disease

Cell Stem Cell, 2009

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DTPND ScienceSites 9/20/23 DTPND ScienceSites 9/20/23

Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration

Cell, 2022

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DTPND ScienceSites 9/20/23 DTPND ScienceSites 9/20/23

Acetylated tau obstructs KIBRA-mediated signaling in synaptic plasticity and promotes tauopathy-related memory loss

Neuron, 2016

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DTPND ScienceSites 9/20/23 DTPND ScienceSites 9/20/23

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

Nature Medicine, 2015

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DTPND ScienceSites 9/20/23 DTPND ScienceSites 9/20/23

Argyrophilic grain disease differs from other tauopathies by lacking tau acetylation

Acta Neuropathologica, 2013

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DTPND ScienceSites 9/20/23 DTPND ScienceSites 9/20/23

Acetylation of tau inhibits its degradation and contributes to tauopathy

Neuron, 2010

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NIAN ScienceSites 9/20/23 NIAN ScienceSites 9/20/23

Tau activation of microglial cGAS–IFN reduces MEF2C-mediated cognitive resilience

Nature Neuroscience, 2023

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NIAN ScienceSites 9/20/23 NIAN ScienceSites 9/20/23

Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy

Nature Communications, 2022

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NIAN ScienceSites 9/20/23 NIAN ScienceSites 9/20/23

AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation

Science, 2021

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NIAN ScienceSites 9/20/23 NIAN ScienceSites 9/20/23

Microglial microRNAs mediate sex-specific responses to tau pathology

Nature Neuroscience, 2020

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NIAN ScienceSites 9/20/23 NIAN ScienceSites 9/20/23

Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia

PNAS, 2017

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Weill Cornell Medicine

Helen & Robert Appel Alzheimer’s Disease Research Institute
413 E. 69th St.
Belfer Research Building 9th Floor
New York, NY 10021
Email: Ana Carney Appel Administrative; Billy Coronas Laboratory Manager

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